Carbon isotopic labelling of carboxylic acids enabled by organic photoredox-catalysed cyanation.

ABSTRACT: The application of molecular imaging has advanced personalized medicine and generated a profound impact on patient care. Positron emission tomography and magnetic resonance imaging are among the most widely used imaging modalities, often requiring the isotopic labelling of bioactive molecules to generate the desired imaging probes. Unfortunately, radiochemistry often limits the development of novel agents due to complicated syntheses and the incompatibility of complex molecules. Here, considering the prevalence of carboxylic acids in drug and bioactive molecules, we have developed a method to perform ^11/13C labelling through carboxylic acid groups via organic photoredox reactions to generate radiolabelled nitriles. We applied this strategy to a range of aliphatic carboxylic acid

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC12383480 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature