Bisphenol E Neurotoxicity in Zebrafish Larvae: Effects and Underlying Mechanisms.

ABSTRACT: As typical environmental hormones, endocrine-disrupting chemicals (EDCs) have become a global environmental health issue of high concern due to their property of interfering with the endocrine systems of organisms. As a commonly used substitute for bisphenol A (BPA), bisphenol E (BPE) has been frequently detected in environmental matrices such as soil and water in recent years. Existing research has unveiled the developmental and reproductive toxicity of BPE; however, only one in vitro cellular experiment has preliminarily indicated potential neurotoxic risks, with its underlying mechanisms remaining largely unelucidated in the current literature. Potential toxic mechanisms and action targets of BPE were predicted using the zebrafish model via network toxicology and molecular docking, with

SUBMITTER: Gu K 

PROVIDER: S-EPMC12383493 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature