Induction of Autophagy as a Therapeutic Breakthrough for NAFLD: Current Evidence and Perspectives.

ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome characterised by hepatic steatosis in the absence of significant alcohol consumption or other specific causes of liver injury. It has become one of the leading causes of liver dysfunction worldwide. However, the precise pathophysiological mechanisms underlying NAFLD remain unclear, and effective therapeutic strategies are still under investigation. Autophagy, a vital intracellular process in eukaryotic cells, enables the degradation and recycling of cytoplasmic components through a membrane trafficking pathway. Recent studies have demonstrated a strong association between impaired or deficient autophagy and the development and progression of NAFLD. Restoring autophagic function may represent a key approach to mitiga

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12383869 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature