Comparative Analysis of Testicular Transcriptional and Translational Landscapes in Yak and Cattle-Yak: Implications for Hybrid Male Sterility.

ABSTRACT: Cattle-yak, a hybrid of yak and cattle, exhibits significant heterosis but male infertility, hindering heterosis fixation. Although extensive research has been conducted on transcriptional mechanisms in the testes of cattle-yak, the understanding of their translational landscape remains limited. In this study, we characterized the translational landscape of yak and cattle-yak based on Ribo-seq technology integrated with RNA-seq data. The results revealed that gene expression was not fully concordant between transcriptional and translational levels, whereas cattle-yak testes exhibited a stronger correlation across these two regulatory layers. Notably, genes that were differentially expressed at the translational level only (MEIOB, MEI1, and SMC1B) were mainly involved i

SUBMITTER: Cao M 

PROVIDER: S-EPMC12383912 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature