Trends in Prostate Cancer Incidence and Survival by Gleason Score from 2000 to 2020: A Population-Based Study in Northeastern Italy.

ABSTRACT: Prostate cancer (PCa) trends have evolved due to changing screening practices. This study assessed long-term trends in PCa incidence and survival according to Gleason score (GS) in Friuli Venezia Giulia, northeastern Italy. A population-based study was conducted, encompassing 21,571 PCa cases from the regional Cancer Registry, diagnosed between 2000 and 2020. Age-standardized incidence rates and 5-year overall (OS) and net survival (NS) were assessed by GS (2-6, 7, 8-10) and age group (<65, 65-74, ≥75). Trends were analyzed using Joinpoint regression. PCa incidence increased from 2000 to 2007 (Annual Percent Change, APC = +1.8%), then declined sharply until 2010 (APC = -7.6%) and remained stable thereafter. Incidence of low-grade cancers (GS 2-6) decreased across all age groups, especially

SUBMITTER: Taborelli M 

PROVIDER: S-EPMC12384114 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature