Oxidation-Active Radical TTM-DMODPA for Catalysis-Free Hydrogen Peroxide Colorimetric Sensing.

ABSTRACT: As a crucial reactive oxygen species, hydrogen peroxide (H2O2) serves as both a physiological regulator and a pathological indicator in human systems. Its urinary concentration has emerged as a valuable biomarker for assessing metabolic disorders and renal function. While conventional colorimetric determination methods predominantly employ enzymatic or nanozyme catalysts, we present an innovative non-catalytic approach utilizing the redox-responsive properties of organic neutral radicals. Specifically, we designed and synthesized a novel radical TTM-DMODPA based on the tris (2,4,6-trichlorophenyl) methyl (TTM) scaffold, which exhibits remarkable optical tunability and oxidative sensitivity. This system enables dual-mode H2O2 quantification: (1) UV-vis spectrophotometry (linear range: 2.5-2

SUBMITTER: Zhong Q 

PROVIDER: S-EPMC12384385 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature