A Preliminary Approach to Oral Low-Dose Ketamine Self-Administration in Mice (Mus musculus).

ABSTRACT: With ketamine gaining attention as a therapeutic drug, oral administration offers an effective alternative to traditional parenteral routes. However, a significant gap remains in understanding its use via voluntary ingestion. This preliminary study aimed to explore the feasibility of oral ketamine self-administration in mice (Mus musculus), while investigating the effects of low concentrations on the brain, liver, and kidney. Adult mice were divided into three groups and received ketamine in their drinking water for 16 days at 0 (control), 5 (K5), or 10 mg/L (K10). A transient decrease in water consumption was observed in both sexes in the K10 group; however, only females in this group showed differences in ketamine intake between groups on some days. Oxidative stress markers measured in t

SUBMITTER: Rocha CA 

PROVIDER: S-EPMC12384402 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature