A Microfluidic Chip-Based Integrated Device Combining Aerosol Sampling and LAMP-CRISPR Detection for Airborne Virus Surveillance.

ABSTRACT: Detecting airborne viruses using an integrated aerosol sampling detection device is of great significance in epidemic prevention and control. Most of the applicable aerosol samplers have a flow rate of less than 1000 L/min, which is insufficient for application in large public spaces. Recent research, on the other hand, has revealed the advantages of microfluidic chip-based LAMP-CRISPR in airborne virus detection; however, this promising detection method has yet to be integrated with an aerosol sampler. Herein, we present an aerosol sampling and microfluidic chip-based detection (ASMD) device that couples a high-flow-rate aerosol sampling (HFAS) system with a microfluidic LAMP-CRISPR detection (MLCD) chip for surveilling airborne viruses, as represented by SARS-CoV-2. The HFAS system achie

SUBMITTER: Zhang A 

PROVIDER: S-EPMC12384654 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature