Age, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study.

ABSTRACT: We investigated associations between maternal grandparents' age and autism spectrum disorders (ASD) in grandchildren, exploring differences by race/ethnicity. In a multigenerational California birth cohort study including 1,743,998 and 1,630,722 mother-child pairs (with 27,975 and 25,816 ASD cases, respectively), we examined ASD risk by grandmother's and grandfather's age at the time when their daughter was born. Logistic regression was used to obtain odds ratios (ORs) and 95% CIs. The odds of ASD in grandchildren were higher among White grandmothers (OR, 1.14; 95% CI, 1.08-1.20) and grandfathers (OR, 1.18; 95% CI, 1.11-1.25) who had daughters at younger ages (18-24 years) compared to the 25-29 year reference, while inverse associations were observed for younger Black grandmothers (OR, 0.8

SUBMITTER: Chow T 

PROVIDER: S-EPMC12384740 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature