Trans-eQTLs Can Be Used to Identify Tissue-Specific Gene Regulatory Networks.

ABSTRACT: Previous high-throughput screening studies have indicated that trans-eQTLs tend to be tissue-specific. This study investigates whether this feature can be used to identify tissue-specific gene regulatory networks. eQTL data for 19,960 genes were obtained from the eQTLGen study. Next, eQTLs displaying both cis- and trans-regulatory effects (p < 5 × 10-8) were selected, and the association between their corresponding genes was examined by Mendelian randomization. The findings were further validated using eQTL data from the INTERVAL study. The trans-regulatory impact of 138 genes on 342 genes was detected (p < 5 × 10-8). The majority of the identified gene-pairs were aggregated into networks with scale-free topology. An examination of the function of genes indicates they are involved in immun

SUBMITTER: Nikpay M 

PROVIDER: S-EPMC12384777 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature