Gut microbiota and diabetic neuropathy/peripheral artery disease: A two-sample Mendelian randomization study investigating risk factors for diabetic foot ulcers.

ABSTRACT: Diabetic foot ulcers (DFUs) represent a significant complication affecting the lower extremities in individuals with diabetes. The development and progression of DFUs are primarily influenced by diabetic neuropathy (DN) and diabetic peripheral artery disease (DPAD). Recent studies indicate a novel link between the gut microbiota and these risk factors. However, it remains unclear whether a causal relationship exists between them. We obtained data on gut microbiota, derived from publicly available genome-wide association studies. Additionally, we included data on DN, diabetic polyneuropathy (DPN), and DPAD from the FinnGen consortium, considering these conditions as primary risk factors for the onset of DFUs. We employed the inverse variance weighting method for the primary effect analysis

SUBMITTER: Tang G 

PROVIDER: S-EPMC12384795 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature