Impact of Treatment Modalities on Locally Advanced Gastric Cancer-Real-World Data.

ABSTRACT: The optimal sequencing of chemotherapy in locally advanced gastric cancer (LAGC) remains controversial. This study aimed to compare survival outcomes between adjuvant (ACT) and neoadjuvant (NACT) chemotherapy and to identify clinicopathological factors associated with progression-free survival (PFS) and overall survival (OS) in a real-world setting. We retrospectively analyzed 103 patients with non-metastatic gastric cancer treated between 2014 and 2024. Patients were categorized into ACT (n = 56) and NACT (n = 47) groups. Kaplan-Meier and Cox regression analyses were used to assess survival outcomes and prognostic factors. The NACT group was younger and had more proximal tumors. Median OS was 48.7 months in the ACT group versus 17.7 months in the NACT group (p = 0.048). Median PFS was not

SUBMITTER: Uguztemur E 

PROVIDER: S-EPMC12384806 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature