Genetic liability to systemic inflammatory regulators is causally linked to COVID-19 diverse phenotypes: Insights from multi-omics association study and single-cell RNA sequencing analysis.

ABSTRACT: Coronavirus disease 2019 (COVID-19) brings heavy burden to patients and society globally. Observational research suggest inflammatory regulators are related to COVID-19. Nevertheless, their causal effects are still unclear. Herein, we performed a Mendelian randomization (MR) analysis to estimate the causality between systemic inflammatory regulators and COVID-19 diverse phenotypes. Genetic instrumental variables associated with systemic inflammatory regulators were extracted from genome-wide association study (GWAS) data involving 8293 European participants. Summary statistics for COVID-19 diverse subtypes were obtained from the COVID-19 host genetic initiative (54,071 cases and 4,905,697 controls). We performed multi-omics approach and MR study to detect the causal links through integrati

SUBMITTER: Liu J 

PROVIDER: S-EPMC12384812 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature