Mendelian randomization analysis of 233 metabolites in chronic rhinosinusitis and nasal polyps.

ABSTRACT: Recent studies have suggested potential associations between specific metabolites and chronic rhinosinusitis (CRS) with nasal polyps (NP). However, robust causal evidence remains limited. This study applies Mendelian randomization (MR) to investigate these relationships. A 2-sample MR design was employed, utilizing genetic variants from publicly available genome-wide association studies. CRS data included 4617 cases and 152,226 controls (ebi-a-GCST90018603), while NP data comprised 5093 cases and 444,966 controls (ebi-a-GCST90018883). Data on 233 circulating metabolites were derived from 33 cohorts, encompassing 136,016 participants. The primary analysis used the inverse variance weighted method, with additional analyses using MR-Egger, simple mode, weighted median, and weighted mode. To a

SUBMITTER: Xun C 

PROVIDER: S-EPMC12384857 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature