Evaluating the Suitability of Perfusion-Based PD Probes for Use in Altered Gravity Environments.

ABSTRACT: Measurable changes in electrophysiology have been documented in spaceflight, creating a pathway for disease genesis and progression in astronauts. These electrophysiology changes can be measured using potential difference (PD). A probe to measure PD was developed and is used clinically on Earth; this probe relies on fluid perfusion to establish an electrical connection to make PD measurements. The changes to fluid behavior in microgravity and partial gravity (including lunar and Martian gravity) drives the need to test this probe in a spaceflight environment. Here, we test the PD probe in a novel nasal cavity phantom in parabolic flight, simulating microgravity, lunar gravity, Martian gravity, and hypergravity conditions across 37 parabolas. The results are evaluated across gravity conditi

SUBMITTER: MacRobbie M 

PROVIDER: S-EPMC12384861 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature