Towards an Implantable Aptamer Biosensor for Monitoring in Inflammatory Bowel Disease.

ABSTRACT: Inflammatory bowel disease (IBD) is a relapsing-remitting condition resulting in chronic inflammation of the gastrointestinal tract. Present methods are either inadequate or not viable for continuous tracking of disease progression in individuals. In this study, we present the development towards an implantable biosensor for detecting interleukin-6 (IL-6), an important cytokine implicated in IBD. The optimised sensor design includes a gold surface functionalised with a known IL-6-specific aptamer, integrating a recognition sequence and an electrochemical redox probe. The IL-6 aptasensor demonstrated a sensitivity of up to 40% and selectivity up to 10% to the IL-6 target in vitro. Sensors were found to degrade over 7 days when exposed to recombinant IL-6, with the degradation rate rapidly i

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12384986 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature