The structural and functional MRI study of graduate students with major depressive disorder and suicidal ideation.

ABSTRACT: Using structural and functional magnetic resonance imaging (fMRI), this study aimed to compare the neuroimaging characteristics of a research group of major depressive disorder (MDD) patients with or without suicidal ideation (SI). 46 graduate students diagnosed with MDD underwent assessment using the Hamilton Depression Rating Scale-24 (HAMD-24) and the Beck Scale for SI (BSI). Based on the BSI assessment, 22 MDD patients with SI were included in the SI group, while 24 patients without SI were included in the non-SI group. Both groups underwent structural and fMRI scans, and voxel-based morphometry, amplitude of low-frequency fluctuations, and functional connectivity (FC) analyses were performed. Compared to the non-SI group, patients in the SI group showed reduced gray matter volume (GMV

SUBMITTER: Li J 

PROVIDER: S-EPMC12385013 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature