Exploring the causal relationship between bipolar disorders and sensory, motor, and behavioral disorders: A bidirectional Mendelian randomization analysis.

ABSTRACT: The interrelationships between bipolar disorder (BD) and sensory, motor, and behavioral disorders are intricate and not well defined. While observational studies indicate potential associations, causal relationships have not been established. This study applies bidirectional Mendelian randomization (MR) analysis to examine potential causal links between BD and these disorders. Bidirectional MR analysis uses summary-level data from genome-wide association studies (GWAS). Genetic instruments are selected according to stringent significance thresholds and linkage disequilibrium (LD) criteria. The primary analytical approaches include inverse-variance weighted (IVW) MR and MR-Egger regression. Instrument strength is assessed using F-statistics. Significant bidirectional associations are identi

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12385034 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature