Adipocyte-specific deletion of gp130 prevents ketogenic diet-induced hepatic steatosis.

ABSTRACT:

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD), the hepatic manifestation of obesity and type 2 diabetes, can progress to metabolic dysfunction-associated steatohepatitis and fibrosis. MASLD is characterized by elevated hepatic lipid accumulation (steatosis) and insulin resistance. The ketogenic diet (KD), a high-fat, low-carbohydrate diet, induces hepatic insulin resistance and steatosis in animal models through unknown mechanisms.

Methods and results

Herein, we investigated the mechanisms behind KD-induced metabolic dysfunction-associated steatohepatitis and fibrosis at thermoneutrality, identifying upregulated inflammatory and lipogenic pathways, including Il-6, Tnf, Mapk13, Lpl, and Pparg. Given the substantial increase in IL-6 during MASLD p

SUBMITTER: Senkalfa B 

PROVIDER: S-EPMC12385040 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature