Concurrence of clozapine-induced diabetic ketoacidosis and neuroleptic malignant syndrome: A case report.

ABSTRACT: Clozapine is a unique antipsychotic drug used to treat treatment-resistant psychosis. Clozapine can induce metabolic complications and weight gain, and may lead to acute diabetic complications such as diabetic ketoacidosis (DKA). Neurological side effects of clozapine are relatively rare compared with those of typical antipsychotics; however, several cases have been reported. In particular, reports have suggested that clozapine-induced neuroleptic malignant syndrome (NMS) may present with atypical features. While multiple reports document DKA and NMS occurring separately in patients receiving clozapine, no cases have been reported in which they occur simultaneously. We report a case in which DKA and NMS developed concurrently, with NMS manifesting atypical features and the significant stre

SUBMITTER: Shin MH 

PROVIDER: S-EPMC12385089 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature