Will diabetes mellitus induce aplastic anemia by immune factors?: A two-sample and mediation Mendelian randomization study.

ABSTRACT: Diabetes is a prevalent global metabolic and endocrine disorder that is associated with a high incidence of complications and organ system dysfunction. Bone marrow (BM) as a previously neglected site of diabetic end-organ damage, characterized by microangiopathy, neuropathy, fat deposition, and inflammation. As a result, diabetes may lead to negative consequences for physiologic hematopoiesis, which may increase the risk of aplastic anemia (AA). Summary genetic data for diabetes mellitus (DM) were sourced from FinnGen; while the data for AA and immune cell traits were obtained from the IEU Open GWAS database. We performed a two-sample univariable Mendelian randomization (MR) analysis to investigate the causal effects of DM on AA. Simultaneously, multivariable MR was utilized to further est

SUBMITTER: Zhong C 

PROVIDER: S-EPMC12385102 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature