Neurobehavioral and metabolic effects of prenatal low-dose chlorpyrifos in C57BL/6J mice.

ABSTRACT: Chlorpyrifos is an organophosphorus insecticide known to produce severe neurotoxicity following early developmental exposure. So far, little data describes the neurobehavioral and metabolic consequences of low-dose exposures, near the threshold to produce cholinesterase inhibition. The purpose of the current study was to characterize the impact of prenatal exposure to a low dose of chlorpyrifos, at 0.5 mg/kg/day, and compare observed neurobehavioral and metabolic changes to a well-defined daily dose of 5 mg/kg. Pregnant C57BL/6 J dams were exposed to either 0, 0.5, or 5 mg/kg/day chlorpyrifos from gestation day 6.5-17.5. A metabolic profile was determined in dams and pups at the end of exposure and behavior was analyzed in offspring during late adolescence and early adulthood. Exposure to

SUBMITTER: Kendricks DR 

PROVIDER: S-EPMC12385724 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature