Gastric Inflammation Impacts Serotonin Secretion in a Mouse Model of <i>Helicobacter pylori</i> Vaccination.

ABSTRACT: Helicobacter pylori infection causes inflammation in the gastric mucosa, and this has been reported to disrupt the gastric microbiota. Serotonin (5-HT) is a key neurotransmitter in the gut-brain axis and plays key roles in intestinal homeostasis and immune function. We investigated gastric serotonin release in H. pylori-infected mice and observed increased release in vaccinated, challenged mice compared to sham vaccinated controls. We investigated the effects of 5-HT on epithelial responses in an in vitro human gastric cancer cell line model (AGS), as well as inflammatory responses and the gastric microbiota in a C57BL/6 mouse model of H. pylori infection. HTR1A was upregulated in the stomachs of mice chronically infected with H. pylori SS1 (3 weeks) compared to

SUBMITTER: Idowu S 

PROVIDER: S-EPMC12386332 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature