Preliminary Investigation of the Association Between Epigenetic Aging Acceleration and Amyloid Biomarkers in Bipolar Disorder.

ABSTRACT:

Objectives

Bipolar disorder (BD) has been associated with an elevated risk of Alzheimer's Disease (AD). We assessed AD biomarkers in BD and tested whether epigenetic aging (EA) acceleration is associated with changes in these markers.

Design, setting, participants

Cross-sectional study of n = 58 living individuals with BD and n = 20 age- and sex-matched control participants, as well as analyses of postmortem brain samples (Brodmann area 9/46) from n = 46 individuals with BD.

Measurements

Amyloid beta (Aβ)₄₀, Aβ₄₂, and total Tau levels were measured in plasma from individuals with BD and controls, and Aβ₄₂ levels were measured in brains. EA and its acceleration (blood: GrimAge and DunedinPACE; brains: DNAmClock_Cortical) were

SUBMITTER: Fries GR 

PROVIDER: S-EPMC12386377 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature