Synthesis, Properties, and Biological Activity Evaluation of Some Novel Naphtho[2,1-e]pyrazolo[5,1-c][1,2,4]triazines.

ABSTRACT: This paper explores a synthetic pathway for naphtopyrazolotriazines utilizing amines as versatile starting materials. The approach leverages the reactivity of amines to construct the triazine core, fused with naphtho and pyrazolo cycles, through a series of controlled diazo coupling and cyclization reactions. By employing amines, this method allows for the introduction of varied substituents, enabling the tailoring of electronic and steric properties to suit specific potential applications. The significance of this work lies in its efficiency, scalability, and potential to synthesize compounds with tunable functionalities. Naphtopyrazolotriazines are of interest due to the presence of a pyrazolo triazine moiety, which is known for its bioactivity, including anticancer and antimicrobial pro

SUBMITTER: Burca I 

PROVIDER: S-EPMC12386420 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature