Venom IMP-L2 from the Ectoparasitoid <i>Scleroderma guani</i> Regulates the IIS/TOR Pathway in <i>Tenebrio molitor</i>.

ABSTRACT: Parasitoid venom significantly influences host physiology and development. Our previous research identified high levels of insulin-binding protein IMP-L2 in the venom of Scleroderma guani. IMP-L2 may inhibit the insulin/insulin-like growth factor signaling (IIS) cascade by competitively binding insulin-like peptides (ILPs) with insulin receptor (InR). However, how to regulate IIS transduction is unclear. We speculate that venom-derived IMP-L2 may bind ILPs to inhibit IIS transduction. Consequently, we investigated the regulation of the IIS/TOR pathway by venom-derived IMP-L2. An expression analysis of IIS/TOR pathway genes across various developmental stages of Tenebrio molitor demonstrated that this pathway governs the entire developmental process. By examining gene expressi

SUBMITTER: Wang W 

PROVIDER: S-EPMC12386756 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature