Differential Sensitivity of Hippocampal GABAergic Neurons to Hypoxia and Ischemia-like Conditions Correlates with the Type of Calcium-Binding Protein Expressed.

ABSTRACT: Using in vitro models of hypoxia, episodes of short-term hypoxia/reoxygenation, and ischemia-like conditions, we were able to establish different sensitivities of hippocampal neurons to their damaging factors. Using a combination of fluorescence microscopy and immunocytochemistry methods, it was possible to show that GABAergic neurons are the most vulnerable to the damaging effects of hypoxia and ischemia-like conditions, as they have a special metabolism, which is characterized by increased production of reactive oxygen species and nitric oxide. It was shown that long-term hypoxia causes the death of GABAergic neurons due to the induction of a global [Ca²⁺]_i increase, whereas pyramidal neurons are resistant to 30-min hypoxia. Episodes of short-term hypoxia/reoxygenat

SUBMITTER: Turovskaya MV 

PROVIDER: S-EPMC12386940 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature