Potential Inhibitors of Human-Naegleria fowleri Interactions: An In Vitro Extracellular Matrix-Based Model.

ABSTRACT: Primary amoebic meningoencephalitis (PAM) is a rapidly progressive and fulminant disease that affects the central nervous system caused by the free-living amoeba Naegleria fowleri. The adhesion to extracellular matrix (ECM) proteins is considered as one of the key steps in the success of the infection and could represent an interesting target to be explored in the prevention and treatment of the disease. In this work, the effect of two sesquiterpenes with proven anti-Naegleria activity on the adhesion of the parasite was evaluated using an in vitro ECM-based model, compared with the reference drugs amphotericin B and staurosporine. Both laurinterol and (+)-elatol inhibited the adhesion of the N. fowleri trophozoites to the main proteins of the ECM when treating them at different concentrat

SUBMITTER: Chao-Pellicer J 

PROVIDER: S-EPMC12387403 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature