Mixed Candida albicans-Staphylococcus aureus Biofilm Is Reduced by Light-Activated Nanocomposite with Phloxine B.

ABSTRACT: Candida albicans and Staphylococcus aureus are opportunistic pathogens that cause life-threatening infections. This study focused on using photodynamic inactivation (PDI) to eliminate mixed biofilms of C. albicans-S. aureus formed on poly (urethane) (PU) discs functionalized with a nanocomposite layer containing phloxine B (PhB). Additionally, the effect of PDI on the ALS3 and HWP1 genes of C. albicans was examined in mixed biofilms. Spectral analysis showed a continuous release of PhB from the nanocomposite in Mueller-Hinton broth within 48 h, with a released amount of PhB < 5% of the total amount. The anti-biofilm effectiveness of the light-activated nanocomposite with PhB showed a reduction in the survival rate of biofilm cells to 0.35% and 31.79% for S. aureus and C. albicans, respecti

SUBMITTER: Czucz Varga J 

PROVIDER: S-EPMC12387639 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature