Mohangic Acid H and Mohangiol: New <i>p</i>-Aminoacetophenone Derivatives from a Mudflat-Derived <i>Streptomyces</i> sp.

ABSTRACT: Streptomyces sp. AWH31-250, isolated from a tidal mudflat in the Nakdong River estuary in Busan, Republic of Korea, was found to produce two novel p-aminoacetophenone derivatives, mohangic acid H (1) and mohangiol (2). Their planar structures were established by comprehensive 1D and 2D NMR spectroscopy, mass spectrometry, and UV analysis, possessing a shorter carbon-chain with a diene moiety, whereas known mohangic acids A-F bear a longer carbon-chain with a triene moiety. The absolute configurations of the key stereogenic centers were determined via computational DP4+ calculations and bioinformatic analysis of the ketoreductase domain sequence from the biosynthetic gene cluster. Based on the careful gene analysis along with whole-genome sequencing, the first pl

SUBMITTER: Son J 

PROVIDER: S-EPMC12387680 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature