Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton.

ABSTRACT: The chirality of tissues and organs is essential for their proper function and development. Tissue-level chirality derives from the chirality of individual cells that comprise the tissue, and cellular chirality is considered to emerge through the organization of chiral molecules within the cell. However, the principle of how molecular chirality leads to cellular chirality remains unresolved. To address this fundamental question, we experimentally studied the chiral behaviors of isolated epithelial cells derived from a carcinoma line and developed a theoretical understanding of how their behaviors arise from molecular-level chirality. We first found that the nucleus undergoes clockwise rotation, accompanied by robust cytoplasmic circulation in the same direction. During the rotation, actin

SUBMITTER: Yamamoto T 

PROVIDER: S-EPMC12387757 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature