Genomic Insights into the Molecular Basis of Broad Host Adaptability of the Entomopathogenic Fungus <i>Conidiobolus coronatus</i> (Entomophthoromycotina).

ABSTRACT: Conidiobolus coronatus (Entomophthorales), a fungal pathogen with a broad insect host range, is a promising candidate for biocontrol applications. We sequenced a C. coronatus strain isolated from a Rhopalomyia sp. cadaver using PacBio long-read sequencing to elucidate the molecular basis of its wide host adaptability. The newly assembled 44.21 Mb genome exhibits high completeness (BUSCO score: 93.45%) and encodes 11,128 protein-coding genes, with 23.1% predicted to mediate pathogen-host interactions. Comparative genomics with the aphid-obligate pathogen C. obscurus revealed significant expansions in gene families associated with host adaptation mechanisms, including host recognition, transcriptional regulation, degradation of host components, detoxification, and

SUBMITTER: Bai F 

PROVIDER: S-EPMC12387763 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature