Whole-body connectome of a segmented annelid larva.

ABSTRACT: Nervous systems coordinate effectors across the body during movements. We know little about the cellular-level structure of synaptic circuits for such body-wide control. Here, we describe the whole-body synaptic connectome of a segmented larva of the marine annelid Platynereis dumerilii. We reconstructed and annotated over 9000 neuronal and non-neuronal cells in a whole-body serial electron microscopy dataset. Differentiated cells were classified into 202 neuronal and 92 non-neuronal cell types. We analyse modularity, multisensory integration, left-right, and intersegmental connectivity and motor circuits for ciliated cells, glands, pigment cells, and muscles. We identify several segment-specific cell types, demonstrating the heteromery of the annelid larval trunk. At the same time, segmen

SUBMITTER: Veraszto C 

PROVIDER: S-EPMC12387772 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature