The GPI-Anchored Aspartyl Proteases Encoded by the <i>YPS1</i> and <i>YPS7</i> Genes of <i>Candidozyma auris</i> and Their Role Under Stress Conditions.

ABSTRACT: Candidozyma auris is a multidrug-resistant, thermo- and osmotolerant yeast capable of persisting on biotic and abiotic surfaces, attributes likely linked to its cell wall composition. Here, seven putative genes encoding yapsins, aspartyl proteases GPI-anchored to the membrane or cell wall, were identified in the genomes of C. auris CJ97 and 20-1498, from clades III and IV, respectively. The C. auris YPS1 gene is orthologous to the SAP9 of C. albicans. The YPS7 gene is orthologous to YPS7 in C. glabrata and S. cerevisiae, so that they may share similar roles. An in silico analysis suggested an interaction between pepstatin and the catalytic domain of Yps1 and Yps7. Although this inhibitor, when combined with caffeine, had a subt

SUBMITTER: Vidal-Montiel A 

PROVIDER: S-EPMC12387857 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature