Evaluating the Impact of Carbon Nanoparticles on the Interfacial Properties of the Pulmonary Surfactant Film.

ABSTRACT: The interaction between carbon nanoparticles (CNs) and Langmuir monolayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) as a model pulmonary surfactant (PS) film was studied to shed light on the physicochemical bases underlying the potential adverse effects associated with pollutant inhalation. The results indicated that the surface pressure-area isotherms of the DPPC monolayers shifted toward lower molecular areas, and the compression modulus was reduced in the presence of CNs, hindering the ability of the DPPC monolayers to reduce the surface tension. The relaxation process of the DPPC monolayers were influenced, and the surface morphology and the continuity of the monolayers were destroyed by the penetration of CNs into the DPPC monolayers. The molecular dynamics simulation rev

SUBMITTER: Geng Y 

PROVIDER: S-EPMC12388053 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature