Quantitative Nuclear Magnetic Resonance Spectroscopy with Overhauser Dynamic Nuclear Polarization.

ABSTRACT: Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for process monitoring. However, the quantitative analysis of highly diluted components or of components in small sample volumes is difficult with this analytical method due to its inherent lack of sensitivity. The hyperpolarization technique Overhauser dynamic nuclear polarization (ODNP) holds promise to solve this problem because it can provide strong signal enhancements. Furthermore, ODNP operates on short time scales and can therefore be used on flowing samples. Despite these advantages, to our knowledge, ODNP has never been applied for quantitative analysis of mixtures-probably because NMR signal enhancements by ODNP can vary greatly for different molecules, making quantitative analysis of mixtures difficult. We demonstr

SUBMITTER: Phuong J 

PROVIDER: S-EPMC12388179 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature