Green Synthesis of Chitosan-Coated Selenium Nanoparticles for Paclitaxel Delivery.

ABSTRACT: Selenium nanoparticles (Se NPs) were synthesized from Na2SeO3 using Foeniculum vulgare (fennel) seed extract as mild sustainable reductant, coated with chitosan (Ch), and loaded with Paclitaxel (PTX). The PTX release from the Se@Ch-PTX NPs and their cytotoxicity against MDA-MB-231 breast cancer cells was studied in view of an application as drug delivery platform. Thermogravimetric analysis (TGA) showed the thermal stability of the NPs up to 300 °C. UV-vis absorption and Fourier transform IR (FT-IR) spectroscopy allowed to trace surface species originating from the F. vulgare extract on the Se NPs, while the surface of the Se@Ch-PTX NPs is characterized from Ch and PTX functionalities. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) showed approximate spherica

SUBMITTER: Al-Darwesh MY 

PROVIDER: S-EPMC12388513 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature