Carborane-Containing Iron Oxide@Gold Nanoparticles for Potential Application in Neutron Capture Therapy.

ABSTRACT: Cancer remains one of the most pressing global health challenges, driving the need for innovative treatment strategies. Boron neutron capture therapy (BNCT) offers a highly selective approach to destroying cancer cells while sparing healthy tissues. To improve boron delivery, Fe3O4@Au nanoparticles were developed and functionalized with a boron-containing carborane compound. Fe3O4 nanoparticles were synthesized and covered by gold, followed by (3-Aminopropyl)triethoxysilane (APTES) modification to introduce amino groups for carborane immobilization. Comprehensive characterization using SEM, DLS, FTIR, EDX, Brunauer-Emmett-Teller (BET), and XRD confirmed successful functionalization at each stage. TEM confirmed the final structure and elemental composition of the nanoparticles. BET analysis

SUBMITTER: Bekbol ZA 

PROVIDER: S-EPMC12388822 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature