Reliability of Automated Amyloid PET Quantification: Real-World Validation of Commercial Tools Against Centiloid Project Method.

ABSTRACT: Background: Despite the growing demand for amyloid PET quantification, practical challenges remain. As automated software platforms are increasingly adopted to address these limitations, we evaluated the reliability of commercial tools for Centiloid quantification against the original Centiloid Project method. Methods: This retrospective study included 332 amyloid PET scans (165 [18F]Florbetaben; 167 [18F]Flutemetamol) performed for suspected mild cognitive impairments or dementia, paired with T1-weighted MRI within one year. Centiloid values were calculated using three automated software platforms, BTXBrain, MIMneuro, and SCALE PET, and compared with the original Centiloid method. The agreement was assessed using Pearson's correlation coefficient, the intraclass correlation coefficient (I

SUBMITTER: Kang YK 

PROVIDER: S-EPMC12389775 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature