Toxicity Assessment of Metyltetraprole, a Novel Fungicide Inhibitor, to Embryo/Larval Zebrafish (Danio rerio).

ABSTRACT: Strobilurins are a prominent class of fungicides capable of entering aquatic environments via runoff and leaching from the soil. Findings from previous studies suggest that strobilurins are highly toxic in aquatic environments, and evidence of acute developmental toxicity and altered behavioral responses have been emphasized. The objective here was to determine the effects of a new strobilurin, metyltetraprole (MTP), on zebrafish using developmental endpoints, gene expression, and behavioral locomotor assays. We hypothesized that MTP would cause developmental toxicity and induce hyperactivity in zebrafish (Danio rerio). To test this, developing zebrafish embryos/larvae were exposed to environmentally relevant levels of MTP (0.1, 1, 10, and 100 µg/L) until 7 days post-fertilization. Surviva

SUBMITTER: Casine T 

PROVIDER: S-EPMC12390205 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature