Derivation of Human Toxicokinetic Parameters and Chemical-Specific Adjustment Factor of Citrinin Through a Human Intervention Trial and Hierarchical Bayesian Population Modeling.

ABSTRACT: Citrinin (CIT) is a mycotoxin produced by various fungi contaminating stored cereals and fruits. While biomonitoring and food occurrence data indicate widespread exposure, its public health risks remain unclear due to the lack of human toxicokinetic (TK) data. A UHPLC-MS/MS method was validated for CIT quantification in capillary blood (VAMS Mitra® tips), feces, and urine obtaining LLOQs ≤ 0.05 ng/mL. A human TK study was conducted following a single oral bolus of 200 ng/kg bw CIT. Individual capillary blood (VAMS Mitra® tips), feces, and urine samples were collected for 48 h after exposure. Samples were analyzed to determine CIT's TK profile. TK modeling was performed using a multi-compartmental structure with a hierarchical Bayesian population approach, allowing robust parameter estimati

SUBMITTER: Visintin L 

PROVIDER: S-EPMC12390278 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature