Exploration of the Roles and Mechanisms Between Tumor-Infiltrating Lymphocytes and Hepatocellular Carcinoma Based on Single-Cell Transcriptomics.

ABSTRACT: Hepatocellular carcinoma (HCC) remains a major global health challenge, with limited effective treatment options, particularly in advanced-stage patients. The tumor immune microenvironment (TIME) plays a crucial role in HCC progression and treatment response, with tumor-infiltrating lymphocytes (TILs) being key modulators of immune activity. In this study, we investigated the immunosuppressive role of TIL-related genes in NASH-associated HCC (NASH-HCC) and identified their potential as independent prognostic factors. We employed Gene Set Enrichment Analysis (GSEA) and Weighted Gene Coexpression Network Analysis (WGCNA) to explore immune suppression in NASH-HCC and identify TIL-related gene modules. Machine learning approaches were utilized to construct a prognostic model, validated using m

SUBMITTER: Shi T 

PROVIDER: S-EPMC12390586 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature