Deciphering Cowpea Resistance to Potyvirus: Assessment of <i>eIF4E</i> Gene Mutations and Their Impact on the eIF4E-VPg Protein Interaction.

ABSTRACT: Cowpea (Vigna unguiculata) is a crop of significant socioeconomic importance, particularly in the semi-arid regions of Africa and America. However, its productivity has been adversely affected by viral diseases, including the cowpea aphid-borne mosaic virus (CABMV), a single-stranded RNA virus. It is known that the VPg protein interacts with the host's translation initiation factor (eIF4E), promoting viral replication. This study aimed to investigate the relationship between mutations in the cowpea eIF4E gene and resistance to CABMV. Twenty-seven cultivars were screened by PCR and bioassays for presence/absence of mutations associated with resistance or susceptibility to Potyviruses. Of the cultivars with mutations previously associated with susceptibility, 88.24% exhi

SUBMITTER: Andrade FA 

PROVIDER: S-EPMC12390716 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature