Case Report: Micronized purified flavonoid fraction [Daflon]-induced bradycardia.

ABSTRACT:

Introduction

Flavonoids are oral venoactive drugs frequently prescribed to relieve the symptoms of chronic venous disorders. Micronized purified flavonoid fraction (MPFF, commercial Daflon 1000 mg) is a preparation that contains mainly diosmin and a small fraction of hesperidin. Both active ingredients are flavonoids, known for their anti-inflammatory and antioxidant properties.

Objective

Whether the MPFF can alter hemodynamic behavior was examined.

Methods

Daflon 1,000 mg was administered for 60 days, and the hemodynamic parameters were measured during the circadian cycle.

Results

There were no significant differences for systolic blood pressure (100.1 ± 10.6 mmHg vs. 104.8 ± 7.7 mmHg) or diastolic blood pressure (73.8 ± 3.1 mmHg vs. 76.4 ± 6.6 mmHg) before an

SUBMITTER: Rodrigues JAL 

PROVIDER: S-EPMC12390788 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature