Abnormal lipid metabolism and atherosclerosis: a new perspective on organelle function regulation and ferroptosis.

ABSTRACT:

Background

Atherosclerosis (AS), characterized by lipid accumulation, contributes significantly to global cardiovascular morbidity. Ferroptosis, an iron-dependent form of cell death triggered by lipid peroxidation, is emerging as a critical player in AS progression. Therefore, our study seeks to elucidate the intricate mechanisms of ferroptosis within the lipid metabolism pathway in AS.

Methods

Differentially expressed genes were identified from the GSE100927 dataset, subsequently isolating AS lipid metabolism-related ferroptosis genes (ASLMRFeGs). Unsupervised cluster analysis was performed on AS samples to identify molecular clusters. WGCNA was performed to uncover module Hub genes. Multiple machine learning models (LASSO, SVM-RFE, RF) were applied to screen Hub genes. Exp

SUBMITTER: Wu X 

PROVIDER: S-EPMC12390804 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature