<i>TP53</i> and <i>KRAS</i> co-mutations are associated with worse outcomes in mucinous ovarian carcinomas.

ABSTRACT:

Objective

Mucinous ovarian carcinomas (mOC) often harbor unique molecular alterations differentiating them from other epithelial ovarian carcinoma subtypes. We sought to characterize the somatic genomic mutation patterns in mOC and elucidate their associations with oncologic outcomes.

Methods

All patients with mOC treated at a single institution between 2005-2023 were identified, and those with validated tumor molecular profiling (TMP) using next-generation sequencing of somatic variants were included. Progression-free survival (PFS) and overall survival (OS) were calculated on a Kaplan-Meier estimator. Multivariable analysis was performed using Cox regression models.

Results

Forty patients were included in this retrospective cohort; 34 (85%) had at least 1 genomic al

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12390820 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature