Microbiota-driven antitumour immunity mediated by dendritic cell migration.

ABSTRACT: Gut microbiota influence the antitumour efficacy of immune checkpoint blockade^1-6, but the mechanisms of action have not been fully elucidated. Here, we show that a new strain of the bacterial genus Hominenteromicrobium (designated YB328) isolated from the faeces of patients who responded to programmed cell death 1 (PD-1) blockade augmented antitumour responses in mice. YB328 activated tumour-specific CD8⁺ T cells through the stimulation of CD103⁺CD11b^- conventional dendritic cells (cDCs), which, following exposure in the gut, migrated to the tumour microenvironment. Mice showed improved antitumour efficacy of PD-1 blockade when treated with faecal transplants from non-responder patients supplemented with YB238. This result suggests that YB328 co

SUBMITTER: Lin NY 

PROVIDER: S-EPMC12390848 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature