Ca²⁺ Inhibits Reactive Oxygen Species Scavenging in Naked Mole-Rat Cortical Homogenates.

ABSTRACT: Deleterious perturbations in reactive oxygen species (ROS) and calcium (Ca²⁺) handling are key initiators of cell death in hypoxia-intolerant mammalian brain. Elevated cellular Ca²⁺ can also inhibit ROS scavengers, exacerbating the deleterious impact of hypoxia on redox homeostasis. Conversely, such perturbations are typically absent in the brain of hypoxia-tolerant animals, including naked mole-rats (NMRs; Heterocephalus glaber), in which a remarkable ability to scavenge ROS has been observed in cardiac and skeletal muscle. We asked if NMR brain possesses a similar ability to detoxify ROS and whether Ca²⁺ impairs ROS scavenging in NMR brain. To test these questions, we used the Amplex ultrared assay to measure the impact of Ca²⁺ on the ability o

SUBMITTER: Jaffer B 

PROVIDER: S-EPMC12390887 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature