A systematic review on the impact of delayed local therapy in patients with Ewing sarcoma of the pelvis.

ABSTRACT:

Background

Local treatment of pelvic Ewing Sarcoma (EWS) is czhallenging due to complex anatomy and potential complications. Local therapy may be deferred to maintain chemotherapy dose-intensity, but the impact of this delay on outcomes remains unclear.

Methods

A systematic review using the PICO model evaluated whether delayed local therapy affects long-term outcomes in localized pelvic EWS. Ovid Medline, Ovid Embase, and Cochrane Central databases were searched through June 2024. Studies were screened by two independent reviewers for quantitative and qualitative data extraction.

Results

Of 1849 studies screened, eight eligible studies including 2618 patients were identified; none were pelvic-specific. When specified, 1-18% had pelvic primaries. All studies were retro

SUBMITTER: Yap SF 

PROVIDER: S-EPMC12390909 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature