Deciphering the Proteomic Profile of the Parasite Fasciola hepatica After Initial Vertebrate Host Infection Reveals New Insights Into Its Early Stages.

ABSTRACT: The migration of the trematode parasite Fasciola hepatica within its vertebrate host following infection by ingestion of the metacercariae represents a critical event in its establishment and survival. The early stages of infection, during which F. hepatica crosses the intestinal barrier and advances to the liver through the peritoneum, initiate changes in the parasite that drive its development from a free-living state on pasture to an obligate blood-feeding parasite. Using an in vivo mouse model, this study explores the proteomic changes in the parasite as it crosses the intestinal barrier and migrates to the peritoneal cavity (24 h post infection (p.i.)) and liver parenchyma (8 days p.i.). This model was coupled with SWATH-MS, enabling a comparative evaluation of parasite protein abunda

SUBMITTER: Lopez-Garcia M 

PROVIDER: S-EPMC12390924 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature